One of those spots is where the tongue, the A-frame up front, joins the main rails. The spring and axle hangers are another, and so are the crossmember welds. Every bump and every load works those joints first, so that's where cracks start.
Then there's salt. The salt and brine on New Hampshire roads can eat crossmembers and frame rails from inside the channel or tube. You won't see it there. So a frame can look solid and still be thin where it counts.
Commercial trailers carry one more rule. The federal rule on vehicle frames says a frame can't be cracked, loose, sagging or broken. It also says a welded frame repair follows the maker's recommendations. That's why we ask for the make and model with the photo.
The coupler end of the tongue is its own subject, and the page on hitch and gooseneck repair covers it.